Ex-Vivo Study, The Effect of Standardized Eurycoma longifolia Extract on The Enzyme Activity of Rosiglitazone N-Demethylase

Eurycoma longifolia (E. longifolia) or also known as Earth Pasak in Indonesia, has been used widely, especially to increase stamina men. The use of herbal medicines the long run opens up opportunities for influence on metabolic process other substances. This study aimed evaluate effect E. extract rosiglitazone metabolism after oral administration one and fourteen days, its rat body weight. rats were divided into two groups, group day treatment (divided 8 subgroups with n = 6: I (control), II VIII (were given at doses 1 1000 mg / kg BW) 14 days (rats 4 subgroups, 6 : IV (treated extracts 5, 25 50 BW). At end experiment, test animals sacrificed N-demethylase activity hepatocytes was determined by measuring amount formaldehid formed 415 nm. all groups analyzed analysis variance (ANOVA) Tukey Test (P <0.05). percentage changing weight compared control group. results showed there a significant increased treated 5 BB, but not significantly different dose BW when For treatment, no difference between group, both enzyme changed